Research Evidence

Research evidence shows the effects of Prelox®  on semen.





* Taking the equivalent of two Prelox capsules a day for 1 month.

Selection Criteria

  • Testicular maldescent
  • Varicocele
  • Orchitis
  • Globozoospermia
  • Infections
  • Hypospadias
  • Severe medical conditions
  • Endocrine hypogonadism

 Study Design

  • DOUBLE BLIND – neither the patient or investigators know the allocation
  • PLACEBO CONTROLLED – the data was compared to taking a placebo tablet to assess the placebo effect
  • CROSS-OVER STUDY – both groups had a chance taking the PRELOX and the placebo in succession.

Prelox Study Design

Patient overview in the study

  • Average age 36
  • 100% compliance with study medication
  • BMI: 26
  • Mean fertility index (at start of the study) 0.53
  • Normogonadotropic
  • Diagnosed as idiopathic infertile


References: 1. Devaraj S, Vega-López S, Kaul N, Schönlau F, Rohdewald P,Jialal I. 2002. Supplementation with a pine bark extract rich in polyphenols increases plasma antioxidant capacity and alters the plasma lipoprotein profile. Lipids 37: 931– 934. 2. Endothelial nitric oxide synthetase Fitzpatrick et al 1998. 3. Hellstrom et al 1994; Zhang and Zheng 1997, Zini et al 1996, Herrero et al 1999. 4. Stanislavov R, Nikolova V, Rohdewald P. 2007. Improvement of erectile function with Prelox®: a randomized, double-blind, placebo-controlled, cross-over trial. Int J Impot Res, Original article, online publication: 1–8. * Stanislavov R, Nikolova V. 2005. Prelox® plus testosterone for achieve fertilization in previously infertile men. Eur Bull DrugRes 13: 7–13.



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